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Synthesis of bisdesmosidic kryptogenyl saponins using the ‘random glycosylation’ strategy and evaluation of their antitumor activity

DOI: 10.1016/j.bmcl.2006.09.071
Title: Synthesis of bisdesmosidic kryptogenyl saponins using the ‘random glycosylation’ strategy and evaluation of their antitumor activity
Journal Title: Bioorganic & Medicinal Chemistry Letters
Volume: 17
Issue: 1
Publication Date: 1 January 2007
Start Page: 156
End Page: 160
Published online: online 10 October 2006
ISSN: 0960-894X
Author: Yang Liua, Dong-Mei Zhaoa, Xue-Hua Lua, Hui Wanga, Hong Chenb, Ying Keb, Ling Lengb, Mao-Sheng Chenga
Affiliations:

  • a Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China

  • b Staff Room of Pharmacognosy, Medical College of Chinese People’s Armed Police Force, Tianjin 300162, PR China
  • Abstract: g>bisdesmosidic steroidal saponins library, composed of 16 novel kryptogenin glycosides, was set up via six random glycosylation procedures, wherein two compounds showed their antitumor activity against HeLa cell in the preliminary pharmacological research.
    Accepted: 22 September 2006
    Received: 9 July 2006
    Revised: 20 September 2006
    Keywords: Steroidal saponins; Kryptogenin glycosides; Random glycosylation; Antitumor activity
    Corresponding information:
    Tel: +86 24 23986413
    Fax: +86 24 23995043
    Email: mscheng@syphu.edu.cn

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