Title: Vacunas y quimioprofilaxis en artritis reumatoide: ?podría plantearse un calendario de vacunación?
Journal Title: Reumatología Clínica
Publication Date: November–December 2011
Start Page: 412
End Page: 416
Published online: online 18 May 2011
Affiliations: Servicio de Reumatología, Hospital Universitario Virgen Macarena, Sevilla, España
Abstract: with rheumatoid arthritis (RA) are at increased risk of infection compared to healthy individuals. The increased risk may be associated with the underlying disease, comorbidities and immunosuppressive therapy required to control RA activity.In several recent studies, influenza, pneumococcal and hepatitis B vaccines administered to RA patients were reported to be safe and serologically effective.However, several lines of evidence suggest a possible aberrant immunologic response following vaccination due to the compromised immunity of these patients. Therefore, vaccination of RA patients prior to immunosuppressive treatment may serve as an alternative prophylactic approach and should be considered for future investigation.Besides, prophylactic health measures should be taken to avoid latent chronic infections as tuberculosis and hepatitis B, during therapy with biological agents.
Accepted: 12 January 2011
Received: 1 November 2010